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“Four-Factor Prothrombin Complex Concentrate (4F-PCC) Off-Label Uses: A Dive into the Guidelines and Literature”

HealthTrust presents...”Four-Factor Prothrombin Complex Concentrate (4F-PCC) Off-Label Uses:  A Dive into the Guidelines and Literature”

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Please Note: Continuing education credit is only available to those attending the session live. CE credit is not available when accessing the program on demand.

Four-factor prothrombin complex concentrate (4F-PCC) has been utilized for various off-label uses, including direct oral anticoagulant reversal in patients experiencing life-threatening bleeding, perioperative management and coagulopathy reversal in patients with liver disease. Best practices are uncertain for off label uses of 4F-PCC due to limited data on the comparative effectiveness of reversal strategies and variability in patient-specific factors. Additionally, there have been controversies associated with dosing, timing, and appropriateness of administration. This presentation will provide education on off-label uses of 4F-PCC and analysis of available literature so that pharmacists can make informed clinical decisions and recognize the appropriateness of 4F-PCC use.

Learning Objectives for Pharmacists   |  At the end of this session, participants should be able to:

  1. Recall the pharmacology of four-factor prothrombin complex concentrate (4F-PCC) and its place in current guidelines.
  2. Identify recent studies that assess the safety and efficacy of 4F-PCC off-label uses.
  3. Recognize the role of the pharmacist in evaluating the appropriateness of 4F-PCC use.


Min Sun “Minny” Jeong, PharmD  |  PGY2 Medication-Use Safety & Policy Pharmacy Resident  |  Ernest Mario School of Pharmacy, Rutgers University

Target Audience: Pharmacists & Physicians

CE Credit: Approved for Pharmacists

This program is approved for CPEs by the Accreditation Council for Pharmacy Education (ACPE). Attendees of this program may earn 1.0 CPE Contact Hours. Belmont University College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. The Universal Activity Number for this activity is 0863-9999-23-041-L01-P. The activity is approved for 1 hour (.1 CEUs) of continuing education credit for pharmacists who attend the webinar and complete the online evaluation.

Note about CE credit: If you plan to obtain credit for a live session, stay until the end of the presentation to receive the verification code you will need to obtain the continuing education credit. CE credit is individual. No group credit is available. Each person must register for a webinar and attend the webinar in its entirety in order to receive an email after the event with instructions on how to apply for continuing education credit. Attendees should not share the code or forward the email to others who did not actually attend the program. If they are not able to be verified on our webinar provider reports and registration list they will not receive credit. If you are joining only by phone, you will not be eligible for credit. You must also log in and join the visual portion of the webinar to be part of our CE provider-required reporting.